Polynucleotides or Profhilo? Your Doctor-Led Guide to Skin Boosting Brilliance
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Polynucleotides (“Fish‑DNA Skin Boosters”)
What They Are
Therapeutic injections made from purified polynucleotides—long DNA fragments derived (ethically!) from salmon or trout sperm. These aren’t sperm cells per se, but regenerative biomolecules that serve as biostimulators in the skin.
Benefits & How They Work
Stimulate natural collagen and elastin production for structural rejuvenation.
Deep hydration by attracting water molecules and enhancing skin moisture retention.
Strong anti-inflammatory and antioxidant action—great for calming redness and restoring irritated skin.
Speed up healing, minimise fine lines, scars.
Effects are natural, subtle, and build gradually over weeks.
Results can last up to about 6 months, sometimes longer with good aftercare.
Ideal For
Delicate regions like under-eye skin, where fillers are too bulky.
Clients who want cellular-level skin repair—the “internal glow-up”.
Those with sensitive or inflamed skin needing gentle regeneration.
Maintenance treatments aimed at prevention and slow, steady improvement.
Profhilo (Pure Hyaluronic Acid Remodeling)
What It Is
A NAHYCO®-technology hyaluronic acid (HA) injectable gel designed to bio-remodel skin rather than volumise. It uses balanced low‑ and high‑molecular-weight HA to gradually hydrate and tighten tissues.
Benefits & How It Works
Deep hydration and radiance via HA binding water in the dermis.
Stimulates collagen and elastin, delivering skin tightening and tone improvement.
Improves texture, elasticity, firmness.
Highly versatile—face, neck, hands, décolletage, even knees or arms.
Treatment is quick, using just 5 injection points on your face(BAP technique), with low downtime.
Results often visible quite quickly, with peak effect around 2–3 months after second session.
Ideal For
Clients with emerging skin laxity, loss of firmness, or dull complexion.
Those wanting a hydra-glow + gentle lift, without changing facial shape.
Preventive maintenance for younger-looking skin in late 20s–30s.
People keen on a minimally invasive, highly hydrating option with efficiency.
Quick Comparison Table
Feature | Polynucleotides | Profhilo |
Mechanism | FIsh-derived DNA stimulates repair | HA stimulates hydration & collagen/elastin |
Major Benefit | Cellular regeneration, inflammation control | Deep hydration & bio-remodeling |
Onset of Results | ~3 weeks, gradual improvement | Immediate glow, peak at ~2–3 months |
Duration of Effects | About 6 months | ~6 months (treatment + maintenance) |
Downtime | Minimal (redness/bruising possible) | Minimal (micro-swelling, mild spots) |
Best Treatment Areas | Under-eyes, face, neck, hands, scars | Face, neck, décolletage, hands & more |
Volume vs. Structure | Doesn’t add volume | Doesn’t add volume. Firms via hydration |
Best For | Sensitive skin, scarred or thin-eyed skin | Mild laxity, dryness, early ageing |
When to Use Which—Clinic Insights
For rejuvenation, repair, and under‑eye renewal: lead with Polynucleotides as the go‑to. It's a match for renewal without fillers.
For tightening, hydration, and overall skin glow: Profhilo shines—especially for clients wanting a quick transformation with a hydration boost.
Combo approach: Ideal patients can benefit from Profhilo first (to hydrate and firm), then Polynucleotides (to regenerate deeper layers), or vice versa depending on priority.
Layering with treatments: Use alongside microneedling, or as a bridge between neuromodulators/fillers.
"Think of Polynucleotides as your skin’s personal coach motivating your skin to behave youthfully again. Meanwhile, Profhilo is more like a deep-soak spa experience for your dermis—hydrating, firming, and making everything bounce with joy"
Whether your skin wants to get its swagger back or just sip up some serious glow, we’ve got the custom approach to deliver what your skin actually needs—no fishy gimmicks (although the DNA origin story is pretty wild).
In Summary
Polynucleotides: love your skin from the inside—regeneration, repair, calm and collagen.
Profhilo: give your skin a skin‑tightening, hydrating revolution with a glowing surface finish.
Clinic tips:
Always consult and tailor: we assess skin condition, expectations, sensitivity, and desired outcome.
Discuss treatment plans: one or two sessions spaced a few weeks apart, and maintenance reshuffles ~6‑month mark.
Pair with skincare that supports collagen and hydration to prolong benefits.
At DermAttract, our doctor-led team in Reigate & Redhill specialises in advanced skin treatments that deliver real, natural-looking results. Whether you’re curious about Profhilo’s glow-inducing hydration or the regenerative power of Polynucleotides, we’re here to guide you with honest, expert advice.
💬 Book your personalised consultation today—no pressure, just medically led insights tailored to your skin goals.
📍 Visit us in Reigate or Redhill
📞 Call us on 07394979615
📩 Or drop us a DM on Instagram @DermAttract
Let your skin heal, hydrate, and glow—beautifully, safely, and expertly with DermAttract.
